MICROBIAL BIOCONVERSION OF POLYPROPYLENE BY YARROWIA LIPOLYTICA: ENHANCING...
Plastic waste can serve as a feedstock for microbial bioconversion using a chemical/biological hybrid strategy. In this work, a bioconversion process for polypropylene (PP) to produce value-added...
View ArticlePROGNOSTIC AND PREDICTIVE BIOMARKERS IN BREAST CANCER
Breast cancer (BC) is a heterogeneous disease consisting of distinct subtypes that vary in prognosis. Routine diagnosis is limited to the assessment of estrogen receptor (ER), progesterone receptor...
View ArticleThe Role of Pyroptosis and Associated Inflammasomes during Experimental...
Human cytomegalovirus (HCMV) is a species-specific β-herpesvirus that establishes a lifelong latent infection in ~80% of the world’s population and can cause severe opportunistic diseases in...
View ArticleRhamnus prinoides Plant Extracts and Pure Compounds Inhibit Microbial Growth...
The increased prevalence of antibiotic resistance threatens to render all of our current antibiotics ineffective in the fight against microbial infections. Biofilms, or microbial communities attached...
View ArticleIMMOBILIZATION OF ENZYMES FROM RHODOCOCCUS RHODOCHROUS DAP 96253 WITH...
Acrylamide (AMD) is an important industrial chemical used in coagulators, water treatment, soil conditioners, mineral refining, paper treatment, adhesives, paints, and petroleum recovering agents. It...
View ArticleBeyond Glycolysis: Pyruvate Kinase M2 Regulates Cancer Cell Glutaminolysis...
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View ArticleDouble-Layered M2e-NA Nanoparticles Induce Broad Protection Against Different...
The development of a universal influenza vaccine is an ideal strategy to eliminate public health threats from influenza epidemics and pandemics. Influenza conserved structures are outstanding...
View ArticleCrystallographic and enzyme kinetics studies of multidrug resistant HIV-1...
HIV/AIDS continues to be a public health threat, with about 1 million people newly infected each year and nearly 40 million deaths from HIV/AIDS since 1980. HIV-1 protease (PR) is an important drug...
View ArticlePost-translational SUMOylation dynamically regulates voltage-gated potassium...
The family of voltage-gated Kv4 ion channels (Kv4.1-3) mediates the transient A-type potassium currents, IA, and is an important regulator of neuronal signaling. Aberrations in Kv4 channel expression...
View ArticleEVALUATION OF NOVEL DRUGGABLE TARGETS AND MECHANISM OF ACTION IN BREAST AND...
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. This lack of expression of...
View ArticleCentral Respiratory Depression: Insight With Murine Models Of Rett Syndrome...
Breathing is generated and controlled by brainstem neurons with several sensory feedback loops, where neurotransmission and neuronal membrane excitability play critical roles. Although such a neural...
View ArticleProtein interactions with heme are vital for pathogenic bacteria,...
Iron is an essential nutrient for many pathogenic bacteria, and the most abundant source of the metal in the host is heme. Heme is often degraded by a heme oxygenase, and the first such enzyme (HO-1)...
View ArticleThe Role of Signal Regulatory Protein Alpha in Hemophagocytic and Cytokine...
The immune system not only eliminates pathogens and other untoward factors but effectively does so without incurring host-compromising collateral damage. Among the many leukocytes buttressing this...
View ArticleAdjuvant Effects on Enhancing Influenza Vaccine Effectiveness and...
Seasonal influenza vaccination is ineffective in conferring cross-protection against antigenically different influenza viruses, particularly in the elderly population. The overarching goal of my...
View ArticleEpigenetic Regulation of Brown Fat Thermogenesis and Hepatic Lipid Metabolism...
Obesity results from a net energy influx due to energy intake exceeding expenditure. Brown fat thermogenesis, an integral part of overall energy expenditure, represents a promising target for the...
View ArticleMulti-omics Approaches to Study Triple-Negative Breast Cancer Metastasis
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that lacks the expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor...
View ArticleNeuropathogenesis of SARS-CoV-2 Infection in Mice
Although severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in humans primarily causes respiratory disease; some patients develop symptoms of neurological disease, such as...
View ArticleEvaluation Of Prognostic Role Of Kinesin Family Member C1 And Its Downstream...
Breast cancer (BC) is a heterogeneous disease with diverse clinicopathological characteristics. Triple-negative BC (TNBC) and quadruple-negative BC (QNBC) are aggressive BC subtypes characterized by...
View ArticleInhibition of FAK-Actin pathway by indoxyl sulfate suppresses arteriogenesis...
Chronic Kidney Disease (CKD) has been implicated in multiple conditions including cardiovascular related diseases and Type 2 Diabetes (T2D). Decreased filtration results in accumulation of urea,...
View ArticleSystemic Administration of PKM2 Preserves Cardiomyocytes and Reduces Cardiac...
Substantial loss of cardiomyocytes during a heart attack and the onset of other cardiovascular diseases is the major cause of morbidity and mortality. Preservation of cardiomyocytes during cardiac...
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