Investigations On The Pathogenesis Of Herpesvirus Retinitis In Mice During...
AIDS is associated with a number of unique sight-threatening retinal diseases that include AIDS-related human cytomegalovirus (HCMV) retinitis and AIDS-related herpes simplex virus type 1 (HSV-1)...
View ArticleAnalysis of Molecular Interactions Between West Nile Virus and Host Cells
Members of the genus Flavivirus are positive-stand RNA viruses that can cause a variety of human diseases, including fever, encephalitis, hepatitis and hemorrhagic fevers. Well-known...
View ArticleAngiogenesis and Endothelial Dysfunction: Insights of Autophagy Machinery in...
Autophagy is an intracellular degradation system that delivers cytoplasmic components to the lysosome for degradation. Autophagy is essential for cellular homeostasis and provides a mechanism to adapt...
View ArticleChronic Exposure to Low Molecular Weight Polycyclic Aromatic Hydrocarbons...
2-naphthol is a low molecular weight polycyclic aromatic hydrocarbon and ubiquitous air pollutant. Recent epidemiological reports suggest that exposure to individual low molecular weight polycyclic...
View ArticleThe TET family proteins regulate skeletal muscle fiber type determination and...
ABSTRACT Brown adipose tissue plays a significant role in ameliorating obesity and other metabolic disorders, and skeletal muscle is a highly adaptable tissue that is essential for maintaining...
View ArticleDiscovering Novel Therapeutics for Triple Negative Breast Cancer
Triple negative breast cancer (TNBC), associated with aggressive tumor behavior and worse outcomes, is the most challenging subtype in breast cancer. Chemotherapy remains the major treatment for TNBC,...
View ArticleSUMOylation as a modulator of ion channel function and expression
The small ubiquitin-like modifier protein (SUMO) is a 12kD peptide that is post-translationally added to target lysine residues. SUMOylation can dynamically regulate a target’s function and expression...
View ArticleInvestigation into Metabolism and Signaling of Hemoglobin in Streptococcus...
Pathogenic bacteria require iron during growth and have evolved elaborated machinery to obtain iron during infection. Most of the host iron is found in heme bound to hemoglobin. This dissertation...
View ArticleA Novel Role of Histone Methyltransferase SMYD2 in Atherosclerosis and Plaque...
Introduction: Clinical manifestation of atherosclerosis is marked by plaque buildup in the brachiocephalic artery (BCA) and vasculature, accompanied by upregulation of mineralization regulating genes...
View ArticlePeripheral Sympathetic Leptin Receptor Signaling Regulates Sympathetic...
The rising prevalence of obesity poses a significant public health challenge, with profound implications for metabolic disorders and associated health risks. In the United States, approximately 40% of...
View ArticleThe Critical Role of Interleukin-6 in Protection against Neurotropic...
West Nile virus (WNV) and Japanese encephalitis virus (JEV) are emerging mosquito-borne flaviviruses that cause encephalitis globally. Interleukin-6 (IL-6) upregulation is associated with viral...
View ArticleMachine Learning Approaches to Predict Neoadjuvant Chemotherapy Response and...
Background: Triple Negative Breast Cancer (TNBC) is an aggressive breast cancer subtype that lacks expression of estrogen (ER), progesterone (PR), and human epidermal growth factor 2 (HER2) receptors....
View ArticleRegulations and Mechanisms of Anaerobic Aromatic Hydrocarbon Oxidation in...
The recalcitrant nature of petroleum hydrocarbons makes the bioremediation of oil-contaminated environments challenging. These contaminants accumulate in environments with limited oxygen, exacerbating...
View ArticleEvolution-Guided Engineering of Elongation Factor-Tu for Incorporation of...
Site-specific incorporation of non-canonical amino acids (ncAAs) has emerged as a promising tool for synthesizing proteins with novel biological properties. However, the breadth of ncAA incorporation...
View ArticleA Temporal Analysis of Acute Cadmium Exposure in Saccharomyces cerevisiae
Cadmium (Cd), a heavy metal found in the earth’s crust, poses a significant health risk as industrialization has resulted in its entry into our food supply. This toxin targets multiple organ systems...
View ArticleNeuropathogenesis of Powassan Virus Infection in Mice
Powassan virus (POWV) is a newly emerging tick-borne neurotropic flavivirus. POWV entry into the central nervous system (CNS) is a critical event determining clinical outcome. Upon successful...
View ArticleModulating Tumor Immunity to Suppress Tumor Progression in Non-small Cell...
Fibrotic stroma and angiogenic tumor vessels play an important role in modulating tumor immunity. We previously reported a rationally designed protein (ProAgio) that targets integrin αvβ3 at a novel...
View ArticleAnalysis of the stress granule response and virus-host protein interactions...
In response to viral infections and other environmental stresses, eukaryotic cells shut down global translation by assembling dynamic cytoplasmic stress granules (SGs). Viruses require cellular...
View ArticleFunctional analysis of simian hemorrhagic fever virus non-structural proteins...
Simian hemorrhagic fever virus (SHFV) is an enveloped, single-stranded, positive sense RNA virus that infects monkeys and has the largest genome (15.7 kb) in the family Arteriviridae. The genome 5′...
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