Biochemical Characterization of the Flavivirus-resistance Mouse ABCF3 Protein...
Mammalian ATP-binding cassette subfamily F member 3 (ABCF3) is a class 2 ABC protein that has previously been identified as a partner of the mouse flavivirus resistance protein 2′,5′-oligoadenylate...
View ArticleRole of Notch1 in acute colitis and colitis associated cancer
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that causes chronic inflammation and ulcers affecting the innermost layer of the colon. Almost 1 million people suffer from UC in the...
View ArticleX-Ray Crystal Structures And Enzyme Kinetic Investigations Of Drug-Resistant...
Globally, 62% of 38 million HIV-infected people are receiving antiretroviral therapy. Inhibitors targeting the viral protease have been clinically successful as 9 protease inhibitors (PIs) have been...
View ArticleIDENTIFICATION OF NOVEL DRUGGABLE TARGETS IN TWO MEMBERS OF MONONEGAVIRALES
Measles virus (MeV) is considered one of the most contagious human viruses and has recently been declared endemic again in several countries despite a highly efficacious vaccine. The viral RNA...
View ArticleHistone Deacetylase-linked Repression and Metabolically-linked Derepression...
Adenovirus (AdV) infection is ubiquitous in the human population and causes acute infection in the respiratory and gastrointestinal tracts. In addition to lytic infections in epithelial cells, AdV can...
View ArticlePre-pilot Fed-batch Fermentation of Rhodococcus rhodochrous DAP 96253 with...
Rhodococcus rhodochrous is a Gram-positive, aerobic, non-pathogenic bacterium ubiquitous in soil. The bacterium exhibits pleomorphic growth and produces orange to red-orange pigmented colonies on...
View ArticleROLE OF MICROBIOME IN IMPACTING TREATMENT OF OBESITY AND TYPE 2 DIABETES
Metabolic Syndrome is a constellation of metabolic abnormalities associated with insulin resistance and obesity, including hyperglycemia and hypertension. Metabolic syndrome often progresses to type 2...
View ArticleDynamic regulation of CD4+ regulatory T cells by radiation treatment
Radiotherapy remains effective at treating primary, early-stage tumors, however it produces nominal results in late-stage and metastatic tumors. This has led to a shift towards more targeted...
View ArticleIdentification and Treatment of Autonomic Dysfunction in Rett Syndrome Mouse...
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View ArticleIL-36R Signaling and Gut Immunity
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract. Cytokines have a critical role in the pathogenesis of IBD, in which they control multiple...
View ArticlePRELIMINARY REPORT ON PROTEIN PREPARATIONS EXHIBITING BOTH ASPARAGINASE AND...
Bacterial L-Asparaginase has been utilized along with chemotherapy in the treatment of acute lymphoblastic leukemia. Current forms of treatment are fraught with undesirable outcomes in a significant...
View ArticleHeme Uptake in Group A Streptococcus: A Role in Physiology and Disease
The Group A streptococcus (GAS) produces millions of infections worldwide, leading to acute diseases, post-infection sequelae, and severe complications. This leading human pathogen requires iron for...
View ArticleDimer Pyruvate Kinase M2 Regulates de novo Collagen Synthesis and...
Fibrosis is a pathologic condition of abnormal accumulation of collagen fibrils. Collagen is synthesized and secreted from myofibroblasts. Collagen is a major extracellular matrix (ECM) protein...
View ArticleHemoglobin and the Host Pathogen Interactions in Streptococcus pneumoniae: a...
Streptococcus pneumoniae is a principal human pathogen that colonizes the human nasopharynx and causes a variety of diseases ranging from common infections to life-threatening conditions such as...
View ArticleMELANOCORTIN-3 RECEPTOR-EXPRESSING NEURONS OF THE VENTRAL TEGMENTAL AREA:...
Over two-thirds of the US population are overweight or obese with obesity’s associated co-morbidities representing 4 out of the 5 leading causes of death. Since the 1970s, a shift in the environment...
View ArticleRNA HELICASE DDX5 REGULATES PLATELET DERIVED GROWTH FACTOR RECEPTORAND...
P68 RNA helicase, a prototypical member of the DEAD box family of RNA helicases is important in many biological processes, including early organ development. However, its aberrant expression...
View ArticleInferences of Glia-Mediated Control in Caenorhabditis elegans
Glia cells are key components of the brain that mediate signaling events between pre- and postsynaptic neurons and that play a vital role in regulating behavior. Depressive disorders are characterized...
View ArticleFunctions of Extracellular Pyruvate Kinase M2 in Fibrosis-related Diseases
Fibrosis represents a pathological condition characterized by excessive deposition of the extracellular matrix. Myofibroblasts are the primary source of extracellular matrix in fibrosis. Their...
View ArticleTherapeutic Targeting Of Stroma Decreases Tumor Progression And Restores...
Cancer-associated fibroblasts (CAFs) comprise a significant portion of the tumor stroma with diverse functions, including matrix synthesis and remodeling, production of growth factors and cytokines,...
View ArticleB Virus Neutralization And Specific Antibody Induction: Each Dependent On...
B virus (BV, Macacine alphaherpesvirus 1), a neurotropic Simplexvirus, is enzootic in macaque monkeys, infects all of the 17 species of the macaque monkeys including Macaca mulatta, M. fascicularis,...
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