Distribution and Dynamics of a Defensive Symbiosis in the Bugula neritina...
Geographical differences in selective pressure may shift the relationship outcome in mutualistic symbioses from positive to negative. The marine bryozoan Bugula neritina is a colonial invertebrate...
View ArticleMicrobiota Metabolism of Soluble Fiber Protects Against Low Grade...
Metabolic syndrome (MetS) is a group of obesity-related metabolic abnormalities that predisposes to type II diabetes mellitus (T2DM) and cardiovascular disease. The dramatic increase in incidence of...
View ArticleIlluminating Actionable Biology in Breast Cancer: Novel Predictive and...
Assessing hormone receptors (the estrogen and progesterone receptors) and the human epidermal growth factor receptor 2 (HER2) to guide clinical decision making revolutionized treatment for breast...
View ArticleINTERVENTION TO EXTRASYNAPTIC GABAA RECEPTORS FOR SYMPTOM RELIEF IN MOUSE...
Rett Syndrome (RTT) is a neurodevelopmental disorder affecting 1 out of 10,000 females worldwide. Mutations of the X-linked MECP2 gene encoding methyl CpG binding protein 2 (MeCP2) accounts for...
View ArticleBiomimicry of Volatile-Based Microbial Control for Mitigating Fungal...
Volatile organic compounds (VOCs) are organic chemicals typically characterized as having low molecular weight, low solubility in water, and high vapor pressure. Consequently, they readily evaporate...
View ArticleCentral Control Of Body Fat And Thermoregulation Through Shared And Separate...
More than 30% of the population suffers from obesity, which increases the risk of death and secondary health problems. Body fat [white adipose tissue (WAT) and brown adipose tissue (BAT)] are...
View ArticlePROAGIO (A PROTEIN DESIGNED TO TARGET INTEGRIN αVβ3)
Large efforts have been made to target integrin αVβ3 of endothelial cells. We have successfully developed a new class of protein (Ref to as ProAgio) by rational protein design using a stable host...
View ArticleComputational Interrogation of Transcriptional and Post-Transcriptional...
The specification and modulation of cell-type specific dendritic morphologies plays a pivotal role in nervous system development, connectivity, structural plasticity, and function. Regulation of gene...
View ArticleRegulation Of Innate Immune Cell Response Under Sub-acute/Chronic...
Sub-acute/chronic inflammatory diseases are often associated with altered inflammatory response, leading to increased host vulnerability to secondary inflammatory challenges. In the first study, by...
View ArticleAnalysis of a Non-canonical Antiviral Mechanism in West Nile Virus-infected...
Upon viral infection, host cells produce type I interferon (IFN), which activates the JAK-STAT signaling pathway and induces the expression of hundreds of interferon-stimulated genes (ISGs) to...
View ArticleGENE REGULATION PATHWAYS AFFECT TOXIN GENE EXPRESSION, SPORULATION AND...
B. anthracis alters its virulence gene expression profile in response to a number of environmental signals, including levels of bicarbonate and CO2. Virulence plasmid pXO1 is important to Bacillus...
View ArticleReprogramming of Myeloid Compartments Supporting Tissue Repair During...
Myeloid-derived suppressor cells (MDSC), emerging during tumor growth or chronic inflammation play a critical role in regulating T cell function. However, mechanisms governing the generation of these...
View ArticleLysine Catabolism and In Vivo Substrate Specificity of D-Amino Acid...
Among multiple interconnected pathways for L-Lysine catabolism in pseudomonads, it has been reported that Pseudomonas aeruginosa PAO1 employs the decarboxylase and the transaminase pathways. However,...
View ArticleStudy of PepT1 and SPAK on Intestinal Homeostasis and Intestinal Inflammation
Inflammatory bowel disease (IBD), mainly including ulcerative colitis (UC) and Crohn’s disease (CD), has become a serious clinical problem in the developed countries. IBD is characterized by...
View ArticleModulation of nontypeable Haemophilus influenza-induced inflammation in the...
Otitis media (OM) is the most common childhood bacterial infection, and leading cause of conductive hearing loss. Nontypeable Haemophilus influenzae (NTHi) is a major bacterial pathogen causing OM....
View ArticleImmune mechanisms of influenza vaccine adjuvants and respiratory syncytial...
Adjuvants have been used for enhancing vaccine-specific immune responses, but the mechanisms of adjuvants and the roles of CD4 in adjuvant effects have been poorly understood. In a conventional model...
View ArticleMolecular Mechanism of Pseudmonas Aeruginosa Responses to Spermine Stress
Pseudomonas aeruginosa can grow efficiently on spermine and other biogenic polyamines via the γ-glutamylpolyamine synthetase (GPS) pathway. Not only subjected to growth inhibition by spermine, the...
View ArticleEFFICACY AND SAFETY OF VIRUS LIKE PARTICLE VACCINES AGAINST RESPIRATORY...
Respiratory syncytial virus (RSV) is a major cause of infectious lower respiratory disease in infants and the elderly. Vaccine-enhanced respiratory disease (ERD) has been a major obstacle in...
View ArticleMicrobial Biofilms: An Evaluation of Ecological Interactions and the Use of...
Biofilms are communities of microorganisms associated with surfaces encased in a protective extracellular matrix. These communities often pose clinical and industrial challenges due to their ability...
View ArticleSymbiont Dependent Host Reproduction In The Marine Bryozoan, Bugula neritina
Larvae of the marine bryozoan, Bugula neritina, are defended from predation by the bryostatins, polyketides synthesized by its uncultured endosymbiont, “Candidatus Endobugula sertula.” Bryostatins are...
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