Design and Production of a Recombinant FliC-Antigen Co-Expression Platform...
The protein monomer of bacterial flagella, FliC, is known to stimulate human innate immunity through activation of Toll-like receptor five. Linking native Salmonella FliC with various antigens has...
View ArticleBenzene and Beyond: Mechanisms of Novel Anaerobic Aromatic Degradation...
Petroleum spills causes contamination of drinking water with carcinogenic aromatic compounds including benzene and cresol. Current knowledge of anaerobic benzene and cresol degradation is extremely...
View ArticleThe role of social and endocrinological context in regulating life history...
During the lifetime of an organism, key events are orchestrated by a confluence of environmental, social, and physiological factors to promote reproductive success. Steroid hormones are critical...
View ArticlePhytocomplexity: Implications For Development Of Novel Anticancer...
Chemotherapy, employing single-molecule or multidrug concoctions inspired by the diverse repository of plant chemicals, has been the mainstay of cancer treatment for years. However, isolating single...
View ArticleMetabolic Activities and Diversity of Microbial Communities Associated with...
Sulfate- and Fe(III)-reducing, and methanogenic prokaryotes (SRP, FRP, MGP) are key players in metabolic pathways involved in anaerobic biodegradation processes. Understanding the metabolic activity...
View ArticlePurification of Soluble Recombinant Salmonella typhimurium Flagellin (FliC)...
A platform for vaccine development has been developed at Georgia State University utilizing recombinant Salmonella typhimurium flagellin (FliC) fused to an antigen that can be overexpressed in...
View ArticleThe role of social and endocrinological context in regulating life history...
During the lifetime of an organism, key events are orchestrated by a confluence of environmental, social, and physiological factors to promote reproductive success. Steroid hormones are critical...
View ArticleCharacterization of DrrAB Complex from Streptomyces Peucetius as A Multidrug...
The soil bacterium Streptomyces peucetius produces two widely used anticancer antibiotics doxorubicin and daunorubicin. Present within the biosynthesis gene cluster in S. peucetius is the drrAB operon...
View ArticleCrystallographic Analysis and Molecular Modeling Studies of HIV-1 Protease...
HIV-1 protease (PR) is an effective target protein for drugs in anti-retroviral therapy (ART). Using PR inhibitors (PIs) in clinical therapy successfully reduces mortality of HIV infected patients....
View ArticleMaintenance of Neuron Activity by Homeostatic Alterations in Receptors and...
Rett Syndrome (RTT) is a developmental disorder that affects numerous neuronal systems that underlie problems with breathing, movement, cognition and sleep. RTT is caused by mutations in the...
View ArticleConduits of Intratumor Heterogeneity: Centrosome Amplification, Centrosome...
Tumor initiation and progression is dependent on the acquisition and accumulation of multiple driver mutations that actiÂvate and fuel oncogenic pathways and deactivate tumor suppressor networks. This...
View ArticleThe Olig Family Member HLH-17 Controls Animal Behavior by Modulating...
In vertebrate and invertebrate systems, the role of glia-neuron interactions during development and behavior is becoming apparent. Recent studies have been aimed at characterizing glial-expressed...
View ArticleElucidation of Mechanisms Underlying Metastatic Melanoma Immune Escape via...
Transcriptional activation of Major Histocompatability Complex (MHC) I and II molecules by the cytokine interferon gamma (IFN-g) is a key step in cell-mediated immunity against pathogens and tumors....
View ArticleCombating the Epigenome: Elucidation of Mechanisms Underlying Chemoresistance...
Chemotherapy and radiation therapy remain the backbone of cancer treatments, and now cancer immunotherapy offers promising new approaches for the treatment of malignancies. One of the major obstacles...
View ArticleDynamic Regulation of the Class II Transactivator by Posttranslational...
The class II Transactivator (CIITA) is the master regulator for Major Histocompatibility Class II (MHC II) molecules. CIITA is dynamically regulated by a series of Posttranslational Modifications...
View ArticleRoles Of Gaseous Neuromodulators NO And CO In Determining Neuronal Electrical...
Throughout neuronal development, bouts of spontaneous electrical activity are critical for the proper wiring of neuronal connections. Alterations in firing activity can affect growth cones, which tip...
View ArticleGenetic, Biochemical, and Functional Characterization of Heme Metabolism in...
Heme is vital to a variety of cellular functions in bacteria ranging from energy generation to iron reserve. Group A streptococcus (GAS) is a prevalent bacterial pathogen that is responsible for an...
View ArticleThe Effects Of Environmental Pollutants On Adipogenesis In The 3T3-L1 Model
Humans are continuously exposed to mixtures of environmental pollutants. Polycyclic aromatic hydrocarbons (PAHs), such as 2-naphthol, and heavy metals, such as lead, are some of these pollutants....
View ArticleRadiation epigenetically modulates tumor cells and alters activation and...
Radiation is a common therapeutic modality for cancer however it fails to control advanced and malignant disease. As a result, novel approaches that aim to stimulate immune attack of tumors are...
View ArticleRole of 26S Proteasome and Regulator of G-Protein Signaling 10 in Regulating...
Major histocompatibility complex molecules (MHCII) are cell surface glycoproteins that present extracellular antigens to CD4+ T lymphocytes and initiate adaptive immune responses. Apart from their...
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